The spread of Mpox virus (MPXV) in Sub-Saharan Africa presents an urgent public health concern with global implications.

MPOX-PROBE is a research project responding to the need for data-driven efforts to identify transmission routes and implement public health initiatives. With activities in three main pillars, (1) improving epidemiological surveillance of Mpox with new diagnostics and sampling efforts including high-risk areas and vulnerable populations, (2) capacity building to
improve diagnostic and research capacities of researchers and public health workers in DRC and RoC and (3) strengthening public health response by sharing surveillance data and newly developed spatiotemporal risk and transmission models for Mpox, the MPOX-PROBE international Consortium will create actionable data to uncover MPXV transmission routes and natural reservoirs facilitating development of effective interventional packages. The transmission and risks models will allow prediction of future or emerging outbreaks and develop initiatives to prevent further spread. Together, these efforts will benefit vulnerable populations and general public in sub-Saharan Africa alike while also performing ground-breaking research to understand transmission mechanisms.